Scientists at NIST recently published an article in the NIST Journal of Research in which they used common everyday diapers to show that volumetric measurements are superior to standard diametric measurements like RECIST 1.1 in determining the true growth of a tumor. In their experiment, they injected water into diapers to simulate a tumor in normal tissue. By continually adding water they were able to simulate the growth of the tumor and image it at each stage. By weighing the diaper they were easily able to determine the mass and volume of the tumor. They found that “With the improved diaper phantoms, the volumetric approach came out on top, outperforming RECIST by at least a factor of five in estimating the mass for each phantom. These experimental results suggest that for real tumors, measuring the volume could be a more reliable predictor of mass than the RECIST length.” They hope that their work will show that volumetric measurements are convincingly better than today’s standard RECIST ones that only rely on length of the tumor in 2D.
Read the article here.